Restoring Erectile Nerve Function at the Source

The first implantable neuromodulation system designed to support natural erectile function recovery, following prostate cancer surgery - when nerve damage is most common. Restoring Erectile Nerve Function at the source.

With support from:
CLINICAL DEVELOPMENT

Rooted in robust science.
Focused on Sexual Health Outcomes.

CaverSTIM™ is currently in clinical trials at leading research centers across the world.

Early Recovery Signals — First-In-Human Study

  • 90% erectile function recovery by 9 months
  • Most regained spontaneous function within weeks
  • Zero safety concerns to date
  • Without PDE5 drugs or invasive therapies

Clinical trials are ongoing to validate long-term safety and efficacy, including pilot studies in the U.S. at Johns Hopkins University School of Medicine and in Australia at the Royal Melbourne Hospital

CaverSTIM™ is an investigational device. Safety and efficacy are being evaluated in clinical trials. This device is not approved for commercial use.

Our Mission
People having a conversation about medical care and treatment options

Mission: To restore sexual health and quality of life for men facing nerve-related erectile dysfunction, starting with prostate cancer surgery.

Vision: To redefine the standard of care for nerve-related erectile dysfunction, and to expand the use of neuromodulation across urologic conditions caused by disrupted nerve signaling.

Learn About Comphya
Prostate cancer survival shouldn't have to cost men their sexual function.

Even with nerve-sparing surgery:

  • 60–70% of men lose erectile function
  • Only 16% recover baseline function
  • Medications mostly don't work when nerves are damaged
  • Pumps, prostheses & injections are invasive and poorly tolerated

Men deserve a restorative solution, beyond disease treatment.

CaverSTIM™ aims to offer that.

Artist conception of human nerve cell showing CaverSTIM technology integration
01

Before Surgery – The Diagnosis

Understanding the Challenge

Prostate cancer is one of the most common cancers in men, with over 400,000 prostatectomies performed each year across the U.S. and Europe. For many, the goal beyond survival is quality of life.

02

During Surgery – Nerve Damage Risk

The Critical Moment

Even with nerve-sparing robotic techniques, microscopic trauma to the cavernous nerves is often unavoidable. Studies show 60-70% of men experience erectile dysfunction following surgery, and fewer than 1 in 5 recover baseline function.

03

After Surgery – The Recovery Gap

The Current Reality

Nerve regeneration can take months or years, and for many, it never fully returns. Current options like pills, injections, pumps and prostheses focus on symptom management — not nerve healing. The impact goes beyond the physical: over 50% of men with post-surgical ED experience depression or loss of confidence, and 1 in 3 report a diminished sense of identity.

04

The Vision – A New Path Forward

Reimagining Recovery

CaverSTIM™ is being developed to enable nerve healing from the critical moment - following surgery - when intervention may have the greatest potential to preserve function and improve long-term outcomes.

CaverSTIM™ is an investigational device not approved for commercial use.

Our Approach

Our technology activates the body's own neural pathways, aiming to restore erectile function in a way that feels natural rather than contrived.

How CaverSTIM™ Works

  • Implanted quickly and easily during prostate cancer surgery: electrodes put in place near the pelvic nerves…
  • … and connected to a slim implantable pulse generator implanted under the skin in the lower abdomen. A programmed daily neurostimulation routine, below the sensory threshold, supports nerve rehabilitation after surgery.
1

Addressing the Root Cause

Supporting Nerve Health at the Source

Instead of treating symptoms after injury, our focus is on protecting and activating those nerves most at risk from prostatectomy — the cavernous nerves essential to erectile function.

2

Timing That Matters

Intervening When Recovery Potential Is Highest

CaverSTIM™ engages nerve pathways during the critical biologic window following surgery — when stimulation may have the greatest impact on long-term recovery.

3

A Smarter, Integrated Solution

Built for Real Clinical Use

Designed to fit seamlessly into standard surgical workflows, CaverSTIM™ integrates neuromodulation technology without adding complexity or additional invasive procedures.

Pioneering a Smarter Surgical Experience

Designed to fit easily into existing work flows — helping providers, patients, and payors rethink male sexual health as part of cancer treatment.

For Providers

Built for seamless surgical adoption

  • Robot-assisted prostatectomy
  • No added surgical session or major workflow change
  • Complements nerve-sparing techniques
  • Supports patient recovery and satisfaction

For Patients

A discreet therapy designed to support natural recovery — not lifelong treatment.

  • Placed during surgery
  • No daily pills, pumps, or injections
  • Designed to empower intimacy and confidence

For Payers

A restorative approach to reduce long-term ED treatment burden

  • 74% of men use PDE5 prescriptions post-RP
  • ED can double work impairment and mental health
  • CaverSTIM™ targets the nerve injury at the source
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Supporting Nerve Function at the Source
CaverSTIM™ is an investigational, implantable neuromodulation system designed to support cavernous nerve signaling following surgery. By delivering targeted stimulation along the nerve pathways (on the pelvic floor) to the nerves most often affected during radical prostatectomy, CaverSTIM™ aims to enable nerve activity at a time when injury can lead to long-term dysfunction. A programmed daily stimulation routine, generally imperceptible, begins at the crucial time for nerve recovery.
CaverSTIM
Implantable Electrode Array

Placed during surgery to align with nerve pathways, no additional procedure needed.

Subcutaneous Pulse Generator

A small, rechargeable unit placed under the skin, programmed by clinicians and tailored to patient needs.

Neuromodulation Protocol

Stimulation begins shortly after surgery, aligning with critical windows for nerve recovery.

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Comphya is pioneering the future of urologic care with innovative neuromodulation technology. Our commitment to improving men's quality of life through precision medical devices represents a new era in post-surgical nerve support.